Healthgevity Serenity Capsules

Serenity was created to support our bodies response to stressful situations and is fast-acting so it can be depended on whenever you need it most.  Serenity features a combination of the latest clinically validated ingredients that are exclusively combined at therapeutic doses. Serenity from Healthgevity is a top natural option for enhancing stress resilience and supporting overall mental and physical well-being.

Elevated stress levels can compromise the immune system, leading to increased irritability, loss of interest, and nervousness. It can also disrupt sleep patterns, resulting in racing thoughts that prevent restful sleep. This, in turn, can strain relationships, reduce productivity, and trigger anger issues. Furthermore, stress can contribute to weight gain through unhealthy coping mechanisms like overeating and impair concentration due to a heightened state of vigilance.

The long-term implications of chronic stress are significant, impacting both physical and mental health. Reducing stress levels is essential for promoting overall well-being, supporting healthy living, and encouraging healthy aging.

FEATURED BENEFITS:

• Supports a healthy stress response

• Promotes an overall sense of calmness

•Helps support relaxation and reduction of nervousness

• Helps maintain healthy cortisol levels during everyday stress

• Maintains healthy neurotransmitter release (Specifically, GABA)

• Promotes both healthy REM & Non-REM sleep cycles

DHH-B (DIHYDROHONOKIOL-B) FROM MAGNOLIA BARK

Magnolia bark plays a central role in traditional Chinese medical formulas as a natural anxiolytic. Honokiol extracted from the bark has been studied independently to investigate its mechanisms of action on the central nervous system and has been shown to interact with neurotransmitter gamma-aminobutyric acid (GABA) receptors. 

A natural variant of honokiol exists with a much better profile, selectivity, and strength of the Honokiol. It is called DHH-B (or dihydrohonokiol-B) and is 20x the strength as the natural Magnolia Bark (Honokiol). DHH-B is a promising compound known for its therapeutic properties, particularly in stress relief, relaxation, and supporting healthy sleep patterns. DHH-B enhances the activity of gamma-aminobutyric acid (GABA), a key inhibitory neurotransmitter that helps reduce neuronal excitability. By increasing GABA activity, DHH-B can improve sleep quality and decrease anxiety levels.

Additionally, DHH-B interacts with the body's endocannabinoid system by activating cannabinoid receptors. This interaction can enhance mood, alleviate pain, and reduce inflammation, providing a comprehensive approach to emotional and physical well-being.   DHH-B has also been shown to lower adrenaline levels, helping to mitigate the physiological effects of chronic and severe stress.

The compound's antioxidant properties further contribute to its neuroprotective and anti-aging effects. DHH-B effectively scavenges reactive oxygen species and enhances the body's endogenous antioxidant defenses, thereby supporting neurological health and protecting against oxidative stress. It also modulates the immune response by influencing the production of pro-inflammatory cytokines.

HOLIXER™ HOLY BASIL EXTRACT

Holy Basil (Ocimum tenuiflorum), also known as Tulsi, has a long history of use in traditional Indian and Asian medical systems. Unlike common culinary basil, Holy Basil is highly revered for its medicinal properties and has been used for centuries in Ayurveda and other traditional practices. Recent research has corroborated the herb's traditional uses, highlighting its potential to support a healthy stress response, enhance sleep quality, and offer anxiolytic and adaptogenic benefits.

Serenity features a specialized form of Holy Basil called Holixer™ which is a patented and extensively researched preparation standardized to contain at least 5% Ocimum Bioactive Complex, a unique blend of bioactive compounds including Rabdosin, Rosmarinic acid, Luteolin-7-o-beta-glucuronide, Ociglycoside I, and Apigenin-7-o-beta-glucuronide.

These bioactive components are thought to contribute to Holy Basil's therapeutic effects. For instance, Rosmarinic acid and Apigenin-7-o-beta-glucuronide have been shown to possess anti-inflammatory and antioxidant properties, which may help mitigate the physiological impact of stress. Luteolin-7-o-beta-glucuronide and Ociglycoside I are known for their potential neuroprotective effects, which could play a role in improving cognitive function and mood stability under stress. Rabdosin, another key component, may aid in balancing the body's stress hormones, thus supporting a more resilient stress response.

In clinical studies, Holixer™ Holy Basil has been observed to promote better sleep by modulating the stress response and reducing the activity of the hypothalamic-pituitary-adrenal (HPA) axis. This, in turn, helps to lower cortisol levels, which are often elevated in individuals experiencing chronic stress. Lower cortisol levels are associated with improved sleep quality and reduced feelings of anxiety.

NATURAL GABA PROBIOTIC L. PLANTARUM 815 (LP815™)

GABA is a major inhibitory neurotransmitter in the central nervous system, playing a crucial role in modulating neuronal excitability and maintaining balance in brain signaling. GABA's primary mechanism of action involves reducing the excitability of neurons, thereby aiding in mood stabilization, stress regulation, and sleep quality. Insufficient GABA levels can result in various health issues, including heightened stress, mood disturbances, poor sleep quality, and impaired cognitive function.

GABA Probiotic  is formulated to provide a sustained release of GABA, offering continuous calming and stress support throughout the day and night. Unlike traditional GABA supplements, which often lead to a rapid but short-lived increase in GABA levels, GABA Probiotic ensures a more stable and prolonged delivery of this neurotransmitter. This is achieved through the use of a proprietary strain of Lactiplantibacillus plantarum, Lp815™, which has been specifically selected for its ability to produce GABA over an extended period.

The choice of Lp815™ is backed by advanced computational modeling and high-throughput screening, allowing for the identification of a strain that outperforms other industry-leading strains in sustained GABA production. The strain's unique capability lies in its robust GABA synthesis in the gastrointestinal tract, leveraging the gut-brain axis—a bidirectional communication pathway between the gut microbiota and the brain. By producing GABA locally in the gut, Lp815™ may influence central nervous system function and mood regulation, providing a dual pathway for enhancing GABA levels.

This sustained production is particularly beneficial compared to traditional GABA supplements, which often require multiple doses throughout the day due to their transient effects. The prolonged release profile of GABA Probiotic reduces the need for frequent redosing, thereby offering a more convenient and consistent option for patients seeking to manage stress and support mood stability.

SAFFRON EXTRACT (AS AFFRON®)

We also included affron® Saffron Extract, which is a highly acclaimed and extensively researched form of saffron, recognized for its rapid and comprehensive effects on both brain and body health. This premium extract has been shown to work within approximately one hour, delivering significant benefits such as reduced oxidative stress, balanced neurotransmitter levels, enhanced neuroplasticity, and improvements in memory and sexual function.

Clinical evidence supports affron® as the most studied saffron extract with eight human clinical studies, demonstrating its ability to improve mood in healthy adults experiencing occasional stress and anxiety.  In a randomized, double-blind, placebo-controlled study, participants who consumed 28 mg/day of affron® for four weeks experienced a 41% improvement in mood, along with a significant reduction in occasional stress, frustration, and tension compared to the placebo group

L-THEANINE (AS L-TEAACTIVE®)

Theanine is an amino acid that is not commonly found in the human diet, as it is not one of the essential or nonessential amino acids. L-theanine is often called a “nondietary amino acid.” Because of its structure, theanine is known to reach the brain quickly following oral consumption. L-theanine is present in various food sources but is found mainly in both green and black teas. 

Theanine is found to be relaxing, but not sedating agent, and has been found to help process stress and to improve attention. It has also been found to aid in sleep quality.

L-Theanine: A Natural Supplement for Anxiety?

Studies show that increasing intake of theanine can significantly reduce symptoms of anxiety, such as a racing heartbeat and increased secretion of immunoglobulin A in saliva. Its effects are somewhat similar to those of a sedative, but L-theanine is far from this prescription drug. It is actually considered to be an effective anxiolytic, which helps to prevent the brain from producing an anxious response to stressful situations.

How Does L-Theanine for Anxiety Work?

L-theanine is processed in the brain through the blood-brain barrier. The blood-brain barrier is similar to a gateway that prevents blood borne substances from crossing over into the brain; it is a form of protection for one of the body’s most important organs. While this barrier is beneficial, it does have its downsides; most notably, it prevents many medications from reaching their target area. Research shows that 98% of small molecule neurotherapies, and 100 percent of large molecule neurotherapies can’t pass through the blood-brain barrier, rendering many types of common treatments for anxiety almost useless.  

L-theanine is different. It uses the leucine-preferring transport system to hitch a ride across the blood-brain barrier, allowing it to target the brain directly. Essentially, theanine is better able to get to where it needs to be efficiently. 

Once past the blood-brain barrier, L-theanine enacts a variety of neurophysiological and pharmacological effects. It has been found to up-regulate inhibitory neurotransmitters, and blocks the binding of L-glutamic acid to glutamate receptors in the brain. It has also been found to potentially modulate serotonin and dopamine in select areas of the brain. L-theanine’s inhibition of cortical neuron excitation can have anti-stress effects.

The three main mechanisms of how L-theanine works in the brain:

Dampens the effects of excitatory brain chemicals
○  L-theanine is reported to target a number of glutamate receptors, including N-methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid (AMPA) and kainite receptors, although at a much lower affinity compared to glutamate

Increases levels of calming and mood-elevating brain chemicals
○  L-theanine also stimulates the production of the calming brain chemicals like γ-aminobutyric acid (GABA), serotonin and dopamine adding to its calming and relaxing effects without sleepiness or impaired motor function

Increases alpha brain waves
○  This increase in alpha wave activity is thought to contribute to L-theanine’s relaxing yet alert effects.

*This is a statement of nutritional support. This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases. Individual results may vary

General Shipping Information

Orders over $75 ship FREE with Standard Shipping
Orders must total $75 before tax (and after any promotional discounts) to qualify. We do not ship internationally at this time.

In most cases, we are able to ship orders placed before 1:00 pm central time on the same day.

Estimated delivery time: 3-5 business days.

Pick Up Orders: pick-up orders placed before 2:00 are generally ready same day. However, we will contact you when the products are ready for pick up in our Bee Cave Alive + Well Store.

Texas Orders: local Austin orders are generally delivered next business day - without any additional fees. Most major Texas cities are also eligible for next business day delivery (call to learn if your city is eligible for next day delivery)

USPS Priority Shipping
Estimated delivery time: 3-5 business days.

2-Day and Overnight: Order must be placed by 12pm CST for processing on same day. Orders placed after 12pm CST on Thursday will ship on Friday and will be delivered on the following Monday (via Overnight) or Tuesday (via 2-Day). Orders placed after 12pm on Friday will ship on the following Monday. 2-Day and Overnight orders cannot be delivered on Saturdays or federal holidays. Not available for delivery to PO Boxes.

Standard Shipping: Orders shipped via standard shipping may be delivered to PO Boxes and APO/FPO/DPO addresses. Shipping carrier and method will be determined by Alive + Well's Shipping Department. Standard shipping time is 3-5 business days.

Shipments outside the continental US: 2-Day and Overnight shipping orders to Alaska and Hawaii are subject to an additional charge of $10.  
Shipments to Puerto Rico can only be done via USPS; 2-Day and Overnight shipping options are not available.

Shipping Refrigerated Products : Our manufacturers formulate their probiotics to ensure their products retain viability until they reach the consumer. Probiotics that are recommended to be refrigerated remain so until the time of shipment, then shipped alongside an ice pack to ensure potency (Note: Ice pack will not arrive frozen, and product may not arrive cold). However, you may want to consider using 2-Day and Overnight shipping methods when purchasing probiotics to ensure maximum potency.

Orders placed on a Thursday-Sunday requiring cold shipping will not ship until the following Monday.

Shipping Address: A safe and accurate address for delivery must be provided at the time the order is placed. Once an order has shipped, Alive + Well is not responsible for lost or stolen packages confirmed to be delivered to the address as entered for the order. If the tracking indicates the package has been delivered, you would be required to place a new order.

AUTOSHIP ORDERS

When you subscribe for Autoship, you'll save 10% on future automatic order (select products do not include a discount on recurring orders). You can skip an order, change the frequency, pause your subscription, or cancel at any time. Your credit card will be billed and the order will be shipped on the same day the order is set to process. You can update your Autoship schedule or make any changes to the order in your online account. You can cancel this schedule at any time.

Additional discounts cannot be applied to autoship products.

Shopping is risk-free with our 30-day return guarantee*. If for any reason you are not satisfied with your purchase, simply send the unused portion back to Alive and Well within 30 days of purchase. Return postage is the responsibility of the customer. You will receive a full refund for the item(s) in the original form of payment. After we process your return, it may take several business days for the refund to appear on your credit card, depending on your financial institution.

*Select products are final sale.

Please note that we are only able to process returns for a maximum of 3 items per year.

Shipping and handling charges are non-refundable. For returns via mail, the product must include your full name, order number and be carefully packaged.  Return postage is the responsibility of the customer.

Once your return has been received, a refund will be issued within 14 days in the original form of payment, and an email confirmation will be sent.

Please return shipments to the following address:

Alive + Well Returns3944 Ranch Road 620Bldg 8, Ste 100Bee Cave, TX 78738

HEALTHGEVITY

Healthgevity has revolutionized the wellness industry by providing the finest quality and most effective nutritional products for the ultimate health-span. Working in tandem with doctors, patients, and scientific researchers, Healthgevity is at the forefront of nutritional technology and personalized wellness. Healthgevity works with professionals to formulate clinical nutrition programs, bringing cutting-edge and advanced science to the emerging industry of functional clinical nutrition. For those suffering from chronic illnesses or focusing on prevention, Healthgevity offers personalized nutrition therapies to support your specific needs.

Healthgevity is built on the unique experiences of healthcare professionals. We have decades of success collaborating with patients, doctors, and other industry leaders to create customized solutions that are truly a win-win for everyone involved. Our focus is to develop formations that improve cellular rejuvenation programming and restore cell health, while utilizing the latest research to support the main accelerators of aging most efficiently.

Everyone wants to look and feel younger. Slow the aging process with Healthgevity. Our products are formulated with the latest research and feature ingredients backed by clinical studies that demonstrate effectiveness, promote regeneration and repair in humans.