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Introducing a powerful, cutting-edge supplement designed to support and enhance healthy NAD+ levels—vital for energy, cellular repair, and overall vitality. This innovative formula combines NMN (Nicotinamide Mononucleotide), a precursor to NAD+, with TMG(Trimethylglycine), which helps optimize methylation and support detoxification. Added Pterostilbene, a potent antioxidant, helps protect cells from oxidative stress while promoting healthy aging, and Apigenin, a natural flavonoid, further supports cellular health and cognitive function. Together, these ingredients work synergistically to elevate NAD+ levels, boost energy support, improve metabolic function, and promote longevity.
Nicotinamide Mononucleotide (NMN): 1,000mg
Key Benefits:
- Boosts NAD+ Levels: NMN is a direct precursor to NAD+, an essential molecule for energy production and cellular repair. By replenishing NAD+, NMN combats age-related declines in mitochondrial function and supports optimal metabolism.
- Supports Longevity Pathways: NMN activates sirtuins, enzymes that regulate DNA repair, inflammation control, and cellular health.
- Enhances Physical and Cognitive Performance: Higher NAD+ levels improve endurance, recovery, and brain function.
Scientific Evidence:
- Studies show NMN supplementation restores NAD+ levels, improving mitochondrial function and lifespan in animal models【1】
- Human trials demonstrate NMN’s ability to enhance blood flow and muscle oxygenation【2】
Trimethylglycine (TMG) (as Betaine Anhydrous): 500mg
Key Benefits:
- Supports Methylation Processes: TMG acts as a methyl donor, critical for processing homocysteine into methionine. This helps maintain healthy DNA and supports NMN's conversion into NAD+.
- Protects Cells from Stress: TMG stabilizes proteins and cell membranes under osmotic stress, ensuring cellular integrity.
- Supports Heart and Liver Health: Helps support homocysteine levels and cardiovascular risk factors.
Scientific Evidence:
- Research highlights TMG’s role in enhancing cellular methylation and metabolic efficiency【3】【4】
- TMG improves physical endurance and energy production in athletes【5】
Pterostilbene: 50mg
Key Benefits:
- Antioxidant Powerhouse: A more bioavailable analog of resveratrol, pterostilbene neutralizes free radicals and protects against oxidative damage.
- Activates Sirtuins: Supports longevity by enhancing sirtuin activity, which depends on NAD+.
- Supports Cognitive Function: Protects brain cells from age-related decline, enhancing memory and focus.
Scientific Evidence:
- Studies suggest pterostilbene is more bioavailable and effective than resveratrol at promoting cellular health【6】【7】.
- Pterostilbene has anti-inflammatory effects, supporting cardiovascular and brain health【8】.
Apigenin: 50mg
Key Benefits:
- Inhibits CD38: Apigenin blocks CD38, an enzyme that depletes NAD+ levels, ensuring more NAD+ is available for critical cellular processes.
- Anti-Inflammatory Properties: Supports chronic inflammation, a key driver of aging and age-related diseases.
- Protects Against Oxidative Stress: Enhances cellular resilience by reducing oxidative damage to DNA, proteins, and lipids.
Scientific Evidence:
- Research confirms apigenin’s ability to inhibit CD38 and increase NAD+ availability【9】【10】.
- Apigenin also shows neuroprotective effects, supporting healthy brain aging【11
The Synergy of Science
By combining these four powerhouse ingredients, NMN 1000+ supports NAD+ production through multiple pathways:
- NMN: Directly replenishes NAD+ levels.
- TMG: Facilitates NMN metabolism via methylation.
- Pterostilbene: Protects and enhances NAD+ and Sirtuin activity.
- Apigenin: Reduces NAD+ depletion by inhibiting CD38.
*This is a statement of nutritional support. This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases. Individual results may vary.

General Shipping Information
Orders over $75 ship FREE with Standard Shipping
Orders must total $75 before tax (and after any promotional discounts) to qualify. We do not ship internationally at this time.
In most cases, we are able to ship orders placed before 1:00 pm central time on the same day.
Estimated delivery time: 3-5 business days.
Pick Up Orders: pick-up orders placed before 2:00 are generally ready same day. However, we will contact you when the products are ready for pick up in our Bee Cave Alive + Well Store.
Texas Orders: local Austin orders are generally delivered next business day - without any additional fees. Most major Texas cities are also eligible for next business day delivery (call to learn if your city is eligible for next day delivery)
USPS Priority Shipping
Estimated delivery time: 3-5 business days.
2-Day and Overnight: Order must be placed by 12pm CST for processing on same day. Orders placed after 12pm CST on Thursday will ship on Friday and will be delivered on the following Monday (via Overnight) or Tuesday (via 2-Day). Orders placed after 12pm on Friday will ship on the following Monday. 2-Day and Overnight orders cannot be delivered on Saturdays or federal holidays. Not available for delivery to PO Boxes.
Standard Shipping: Orders shipped via standard shipping may be delivered to PO Boxes and APO/FPO/DPO addresses. Shipping carrier and method will be determined by Alive + Well's Shipping Department. Standard shipping time is 3-5 business days.
Shipments outside the continental US: 2-Day and Overnight shipping orders to Alaska and Hawaii are subject to an additional charge of $10.
Shipments to Puerto Rico can only be done via USPS; 2-Day and Overnight shipping options are not available.
Shipping Refrigerated Products : Our manufacturers formulate their probiotics to ensure their products retain viability until they reach the consumer. Probiotics that are recommended to be refrigerated remain so until the time of shipment, then shipped alongside an ice pack to ensure potency (Note: Ice pack will not arrive frozen, and product may not arrive cold). However, you may want to consider using 2-Day and Overnight shipping methods when purchasing probiotics to ensure maximum potency.
Orders placed on a Thursday-Sunday requiring cold shipping will not ship until the following Monday.
Shipping Address: A safe and accurate address for delivery must be provided at the time the order is placed. Once an order has shipped, Alive + Well is not responsible for lost or stolen packages confirmed to be delivered to the address as entered for the order. If the tracking indicates the package has been delivered, you would be required to place a new order.
AUTOSHIP ORDERS
When you subscribe for Autoship, you'll save 10% on future automatic order (select products do not include a discount on recurring orders). You can skip an order, change the frequency, pause your subscription, or cancel at any time. Your credit card will be billed and the order will be shipped on the same day the order is set to process. You can update your Autoship schedule or make any changes to the order in your online account. You can cancel this schedule at any time.
Additional discounts cannot be applied to autoship products.
Shopping is risk-free with our 30-day return guarantee*. If for any reason you are not satisfied with your purchase, simply send the unused portion back to Alive and Well within 30 days of purchase. Return postage is the responsibility of the customer. You will receive a full refund for the item(s) in the original form of payment. After we process your return, it may take several business days for the refund to appear on your credit card, depending on your financial institution.
*Select products are final sale.
Please note that we are only able to process returns for a maximum of 3 items per year.
Shipping and handling charges are non-refundable. For returns via mail, the product must include your full name, order number and be carefully packaged. Return postage is the responsibility of the customer.
Once your return has been received, a refund will be issued within 14 days in the original form of payment, and an email confirmation will be sent.
Please return shipments to the following address:
Alive + Well Returns3944 Ranch Road 620Bldg 8, Ste 100Bee Cave, TX 78738